If you’re in search of a hearty, flavor-packed dish that’s sure to become a family favorite, look no further than this Southwest Chicken Bake. This one-dish wonder combines tender chicken breasts with zesty enchilada sauce, creamy sour cream, and a melty cheese topping, resulting in a delightful meal that’s simple to prepare. Perfect for busy weeknights or when entertaining guests, this dish brings the bold flavors of the Southwest right to your table.
Top Reasons to Make Southwest Chicken Bake

- Quick and Easy: With minimal prep and one baking dish, cleanup is a breeze!
- Flavor Explosion: The combination of enchilada sauce and diced tomatoes with green chilies creates a mouthwatering flavor profile.
- Versatile: Customize it with your favorite toppings or sides, making it adaptable to your family’s tastes.
- Meal Prep Friendly: It’s perfect for meal prepping, allowing you to enjoy leftovers throughout the week.
Gather These Ingredients
- 4 boneless, skinless chicken breasts
- Salt and pepper to taste
- 1 can (15 ounces) enchilada sauce
- 1 can (14.5 ounces) diced tomatoes with green chilies, drained
- 8 ounces sour cream
- 1 cup shredded Mexican cheese blend
- Chopped fresh cilantro for garnish
- Cojita cheese for additional flavor
- Tortilla chips or strips for serving
Equipment Breakdown
- Baking Dish: A 9×13 inch dish works perfectly for this recipe.
- Mixing Bowl: For combining the sour cream and other ingredients.
- Measuring Cups and Spoons: Essential for getting the right quantities.
- Knife and Cutting Board: To prepare the chicken and cilantro.
- Oven: Preheat to ensure even baking.
Cook Southwest Chicken Bake Like This

Step 1: Preheat the Oven
Preheat your oven to 375°F (190°C). This ensures the chicken cooks evenly and the cheese melts beautifully.
Step 2: Season the Chicken
Season the 4 boneless, skinless chicken breasts with salt and pepper on both sides. This simple seasoning enhances the overall flavor.
Step 3: Prepare the Sauce Mixture
In a mixing bowl, combine the 15 ounces of enchilada sauce and the drained 14.5 ounces of diced tomatoes with green chilies. Stir until well mixed.
Step 4: Layer the Ingredients
Spread a thin layer of the sauce mixture on the bottom of your baking dish. Place the seasoned chicken breasts on top, and then pour the remaining sauce mixture over the chicken.
Step 5: Add the Creaminess
Dollop the 8 ounces of sour cream over the top of the chicken and sauce. Use a spatula to spread it evenly for creamy goodness in every bite.
Step 6: Cheese It Up
Sprinkle 1 cup of shredded Mexican cheese blend over the sour cream layer. This will create a deliciously gooey top once baked.
Step 7: Bake to Perfection
Cover the baking dish with aluminum foil and bake in the preheated oven for 30 minutes. Remove the foil and bake for an additional 10-15 minutes, or until the chicken is cooked through and the cheese is bubbling and golden.
Step 8: Garnish and Serve
Once baked, remove from the oven and let it rest for a few minutes. Garnish with chopped fresh cilantro and crumbled cojita cheese. Serve with tortilla chips or strips on the side for an extra crunch!
Health-Conscious Tweaks

- Use Greek yogurt instead of sour cream for a lighter option.
- Swap out the shredded cheese for a reduced-fat cheese blend to cut calories.
- Add in some black beans or corn for added fiber and nutrients.
- Serve over a bed of quinoa instead of tortilla chips for a healthier grain option.
Behind-the-Scenes Notes
This Southwest Chicken Bake is not only easy to make, but it also leaves room for creativity. Feel free to add in your favorite vegetables, such as bell peppers or onions, for an extra layer of flavor and nutrition. The recipe can be made ahead of time, making it perfect for meal prep or entertaining. Simply assemble the dish, cover it with foil, and refrigerate until you’re ready to bake!
Keep-It-Fresh Plan
- Store leftovers in an airtight container in the fridge for up to 4 days.
- Reheat individual portions in the microwave for a quick meal.
- For longer storage, freeze the assembled but unbaked dish. When ready to enjoy, thaw overnight in the fridge and bake as directed.
Handy Q&A
Can I use frozen chicken breasts for this recipe?
Yes, you can use frozen chicken breasts. However, you may need to increase the baking time to ensure they are thoroughly cooked. It’s best to thaw them beforehand for more even cooking.
What can I substitute for enchilada sauce?
If you don’t have enchilada sauce, you can use taco sauce or a homemade blend of tomatoes, spices, and chili powder for a similar flavor profile.
Can I make this dish vegetarian?
Absolutely! Substitute the chicken with black beans, chickpeas, or a variety of vegetables like zucchini and bell peppers for a delicious vegetarian version of this Southwest Chicken Bake.
What sides pair well with this dish?
Serve with a fresh green salad, Mexican rice, or even some roasted vegetables for a well-rounded meal. Tortilla chips or a side of guacamole complement the flavors wonderfully!
What to Make After This
- Cheesy Vegetable Enchiladas
- Southwest Chicken Salad
- Vegan Black Bean Burrito Bowl
- Best Chocolate Chip Cookies for dessert!
Ready to Cook?
Now that you have all the tips and tricks for making the perfect Southwest Chicken Bake, it’s time to gather those ingredients and get started! This dish promises to deliver a burst of flavor and satisfaction with every bite. Whether for a family dinner or a fun gathering with friends, this Southwest Chicken Bake is sure to impress. Enjoy the process, and most importantly, savor the delicious results!

Southwest Chicken Bake
Equipment
- Baking dish (9x13 inch)
- Mixing Bowl
- Measuring cups and spoons
- Knife and cutting board
- Oven
Ingredients
- 4 boneless, skinless chicken breasts
- Salt and pepper to taste
- 1 can (15 ounces) enchilada sauce
- 1 can (14.5 ounces) diced tomatoes with green chilies drained
- 8 ounces sour cream
- 1 cup shredded Mexican cheese blend
- Chopped fresh cilantro for garnish
- Cojita cheese for additional flavor
- Tortilla chips or strips for serving
Instructions
- Preheat your oven to 375°F (190°C). This ensures the chicken cooks evenly and the cheese melts beautifully.
- Season the 4 boneless, skinless chicken breasts with salt and pepper on both sides. This simple seasoning enhances the overall flavor.
- In a mixing bowl, combine the 15 ounces of enchilada sauce and the drained 14.5 ounces of diced tomatoes with green chilies. Stir until well mixed.
- Spread a thin layer of the sauce mixture on the bottom of your baking dish. Place the seasoned chicken breasts on top, and then pour the remaining sauce mixture over the chicken.
- Dollop the 8 ounces of sour cream over the top of the chicken and sauce. Use a spatula to spread it evenly for creamy goodness in every bite.
- Sprinkle 1 cup of shredded Mexican cheese blend over the sour cream layer. This will create a deliciously gooey top once baked.
- Cover the baking dish with aluminum foil and bake in the preheated oven for 30 minutes. Remove the foil and bake for an additional 10-15 minutes, or until the chicken is cooked through and the cheese is bubbling and golden.
- Once baked, remove from the oven and let it rest for a few minutes. Garnish with chopped fresh cilantro and crumbled cojita cheese. Serve with tortilla chips or strips on the side for an extra crunch!
Notes
- Substitute Greek yogurt for sour cream to make a lighter version of this dish.
- Add black beans or corn to increase fiber and nutrition.
- Store leftovers in an airtight container in the fridge for up to 4 days.
- Freeze the assembled but unbaked dish for longer storage; thaw overnight before baking.
- Customize with vegetables like bell peppers or onions for added flavor.
