Place the chicken breasts in a resealable plastic bag or shallow dish.
In a mixing bowl, whisk together the buttermilk, minced garlic, honey, 2 tsp kosher salt, and 1 tsp black pepper until combined.
Pour the buttermilk mixture over the chicken, seal or cover, and refrigerate for a few hours or up to overnight.
Preheat the oven to 400°F (200°C) and place a wire rack on a rimmed baking sheet.
In a shallow bowl or plate, combine the panko breadcrumbs, grated Parmesan, garlic powder, Italian seasoning, paprika, and a pinch of salt and pepper.
Remove each chicken breast from the marinade, letting excess drip off, then press both sides into the panko mixture to coat evenly.
Arrange the coated chicken on the wire rack set over the baking sheet and lightly spray the tops with cooking spray.
Bake for 20 to 25 minutes, until the chicken reaches an internal temperature of 165°F (74°C) and the coating is golden and crisp.
Remove from the oven and let rest briefly before serving.