Preheat the oven to 400°F (200°C). Lightly spray or brush a 9x13 inch casserole dish with nonstick spray or olive oil.
Place the 2 pounds of boneless chicken thighs in a large bowl and drizzle with 2 tablespoons olive oil; toss to coat.
In a small bowl, stir together 2 tablespoons brown sugar, 1/2 tablespoon paprika, 1 teaspoon Italian seasoning, 1/2 teaspoon garlic powder, 1/2 teaspoon onion powder, 1 teaspoon salt, and 1/4 teaspoon black pepper.
Rub the spice mixture all over the chicken thighs so they are evenly coated.
Arrange the coated chicken thighs in a single layer in the prepared baking dish.
Bake uncovered for 30–35 minutes, or until the internal temperature reaches 165°F (74°C).
Remove from the oven and let rest a few minutes before serving.