Preheat the oven to 400°F. Lightly grease a baking sheet.
Pat the 46-ounce cod fillets dry with paper towels and place them on the prepared baking sheet in a single layer with a little space between each fillet.
In a small bowl, combine 1/2 cup panko breadcrumbs, 1 tablespoon olive oil, 1/4 teaspoon garlic powder, 1/4 teaspoon paprika, 1/4 teaspoon kosher salt, and 1/4 teaspoon black pepper. Stir until the panko is evenly moistened.
Evenly sprinkle the panko mixture over the tops of the cod fillets. Press the mixture gently onto each fillet so it adheres.
Bake in the preheated oven for 12–15 minutes, or until the crust is golden and the fish flakes easily with a fork.
Sprinkle the baked fillets with 2 tablespoons finely chopped fresh parsley. Serve immediately with the lemon cut into wedges on the side.