In a medium bowl whisk together the flour, chili powder, kosher salt, black pepper, and cayenne until evenly combined.
Add the egg and milk to the seasoned flour and whisk until smooth to form a wet batter.
Place the panko breadcrumbs in a separate shallow bowl and set a plate nearby for the coated chicken.
One at a time, dip each chicken tender into the batter to coat, then press into the panko until thoroughly coated; transfer to the plate.
Stovetop option: Heat 2 tablespoons olive oil in a large skillet over medium-high until shimmering. Add half the chicken in a single layer and cook undisturbed about 2 minutes per side, or until golden and cooked through; repeat with remaining chicken.
Oven option: Preheat the oven to 425°F (220°C). Set a wire rack on a rimmed baking sheet and lightly grease the rack. Arrange the crumb-coated tenders on the rack, spray or brush with olive oil, and bake 10 minutes or until cooked through.
Transfer the cooked chicken to a serving plate, squeeze lime wedges over the pieces, and drizzle with the honey just before serving.