Preheat the oven to 400°F (200°C) and line a baking sheet with parchment paper.
In a large bowl, combine the ground beef, gluten-free breadcrumbs, grated Parmesan, egg, chopped parsley, garlic powder, onion powder, salt, black pepper, and dried oregano.
Mix gently until just combined, taking care not to overwork the meat so the meatballs stay tender.
Shape the mixture into 1½-inch meatballs and place them evenly spaced on the prepared baking sheet.
Bake for 20–25 minutes, until the meatballs are cooked through and register 165°F (74°C) internally.
Notes
Do not overmix the meat to keep meatballs tender.
Use an instant-read thermometer for accurate doneness.