Pat the chicken dry and place in a bowl; add the taco seasoning, onion powder, garlic powder, and kosher salt, then toss to coat evenly.
Heat 1 tablespoon olive oil in a large skillet over medium heat.
Add the seasoned chicken pieces and cook, stirring occasionally, until browned and cooked through, about 4–5 minutes; remove from the skillet and set aside.
Pour about 1 cup of oil into the skillet and heat over medium until shimmering; test by dipping the edge of a chalupa—bubbles should form.
Using tongs, fold each chalupa tortilla in half to form a shell and fry one half in the hot oil until golden, then flip and fry the other half until evenly golden and crisp; drain on paper towels.
Fill each fried chalupa shell with cooked chicken, about 1/8 of the shredded cheese, then top with shredded lettuce, diced tomatoes, sour cream, and salsa to taste.