Place the chicken tenderloins in a large bowl and pour the buttermilk over them; stir to coat. Cover and refrigerate while you prepare the coating and hot honey.
In a shallow dish, whisk together the flour, paprika, salt, and ground black pepper until evenly combined.
In a small bowl, whisk the honey, hot sauce, and red pepper flakes; adjust heat to taste and set aside.
Remove a few tenderloins from the buttermilk, letting excess drip off, then dredge thoroughly in the flour mixture to coat all sides. Repeat until all pieces are coated.
Heat 1/4 cup oil in a large skillet over medium heat until shimmering. Add chicken in a single layer without crowding; cook in batches if needed.
Cook each side about 3–5 minutes, flipping once, until the exterior is golden and an instant-read thermometer inserted into the thickest part reads 165°F (74°C). Reduce heat to medium-low if the outside browns too quickly.
Transfer cooked tenders to a paper towel–lined plate. Add more oil to the skillet between batches if it becomes dry, and repeat until all chicken is cooked.
Arrange the cooked tenders on a platter and drizzle the prepared hot honey evenly over them, or serve the hot honey on the side for guests to add their own.