Preheat the oven to 450°F (232°C). Line a baking sheet with foil and set a wire rack on top; spray the rack lightly with nonstick spray.
Season the chicken tenders evenly with 1/4 teaspoon salt and 1/4 teaspoon black pepper.
Place the pretzel twists in a food processor and pulse until mostly fine crumbs remain, or crush in a bag with a rolling pin. Transfer crumbs to a shallow bowl and stir in 1 teaspoon garlic powder.
In another shallow bowl, lightly beat the two eggs.
Dip each seasoned chicken tender into the beaten egg, then press into the pretzel crumbs so they adhere. Arrange coated tenders on the prepared wire rack. Repeat with remaining chicken.
Lightly spray the tops of the coated chicken with olive or avocado oil spray. Bake for 12 minutes, flip each tender, spray the other side, then bake an additional 10–12 minutes until the chicken is cooked through and crust is golden.
Meanwhile, make the hot honey: combine 1/2 cup honey and the sliced jalapeño in a small saucepan over medium-low heat and bring just to a light simmer. Remove from heat and let steep for 5 minutes, then strain through a fine mesh sieve to remove solids and seeds.
Whisk together the mayonnaise, 2 tablespoons Dijon mustard, 1 tablespoon yellow mustard, 1 tablespoon honey, and 1 tablespoon BBQ sauce until smooth to make the house sauce.
Let the chicken cool slightly, then serve with the house sauce and drizzle or serve the hot honey alongside.