Set the Instant Pot to Sauté and heat. Add the ground beef and cook, breaking it up with a wooden spoon, until fully browned, about 5 minutes.
Turn off Sauté and carefully drain any excess grease from the pot.
Return the pot (if removed) and add the Stone House Seasoning, dried oregano, crushed tomatoes (28-ounce can), and 4.5 cups water; stir to combine.
Lay the broken spaghetti noodles on top of the meat and sauce so they are mostly submerged; add a little more water only if needed to ensure the noodles are covered.
Secure the lid and cook at high pressure for 8 minutes. When done, perform a quick release to release remaining pressure.
Remove the lid and stir the spaghetti and sauce until combined and noodles are separated.
Serve portions topped with grated Parmesan cheese.