Preheat the oven to 350°F (175°C) and lightly spray a 9×13-inch baking dish with nonstick cooking spray.
Bring a large pot of salted water to a boil. Cook the campanelle pasta according to package directions until al dente, then drain and set aside.
In a 12-inch skillet over medium-high heat, cook the ground beef until no longer pink, breaking it up with a meat masher or spatula; drain any excess grease.
Add the taco seasoning, 3/4 cup water, and the undrained Rotel to the cooked beef. Stir, then simmer over medium heat for about 5 minutes.
Remove the skillet from heat and stir in the jar of salsa con queso, heavy cream, chili powder, onion powder, and garlic powder until combined.
Stir the drained pasta into the beef and sauce mixture, then mix in 1 cup of the shredded cheddar cheese. Taste and season with salt and black pepper if desired.
Transfer the pasta mixture to the prepared 9×13-inch baking dish and sprinkle the remaining 1 cup of shredded cheddar cheese evenly over the top.
Bake for 20 minutes, then remove from the oven, top with the crushed Doritos, and return to the oven for an additional 5–10 minutes until bubbly.