Chicken Alfredo Lasagna Casserole

If you love creamy, cheesy pasta dishes but are looking for something a little different than your typical lasagna, this Chicken Alfredo Lasagna Casserole is a dream come true. Layers of tender lasagna noodles, shredded chicken, rich ricotta, and gooey mozzarella come together with a luscious Alfredo sauce to create a comforting meal that’s perfect for family dinners or special occasions. It’s like your favorite Italian restaurant dish, but made at home with ease and plenty of flavor. Ready to dive into a dish that’s both hearty and indulgent? Let’s get started.

Why You’ll Love This Recipe

There’s a reason this casserole is a go-to for many pasta lovers. First, it combines the best of two worlds: the classic layers of lasagna and the creamy, garlicky goodness of Alfredo sauce. Unlike traditional red-sauce lasagna, this recipe offers a smooth, velvety texture that’s incredibly satisfying. Plus, the shredded chicken adds a protein boost, making it a complete meal in one dish.

It’s also super versatile. You can prep it ahead of time and bake it when you’re ready, making it a great option for busy weeknights. The combination of cheeses—ricotta, mozzarella, and Parmesan—melts perfectly and creates that irresistible golden crust on top. And don’t worry about complicated steps; this casserole keeps things straightforward without sacrificing flavor.

The Ingredient Lineup

• 12 lasagna noodles – Regular or no-boil noodles work well here; just make sure to cook them al dente if boiling.
• 2 cups cooked chicken, shredded – Rotisserie chicken or oven-baked chicken breasts shredded into bite-sized pieces.
• 2 cups ricotta cheese – Adds creaminess and depth to the layers.
• 3 cups shredded mozzarella cheese – For that stretchy, melty goodness.
• 1 cup grated Parmesan cheese – Adds a nutty, salty finish.
• 3 cups Alfredo sauce – Use a homemade or store-bought creamy Alfredo sauce rich with garlic and butter flavors.
• 1 teaspoon garlic powder – Enhances the savory notes.
• 1 teaspoon Italian seasoning – A blend of herbs like basil, oregano, and thyme to bring warm, aromatic flavors.
• Salt and pepper to taste – To balance and enhance the flavors.
• Fresh parsley for garnish – Adds a pop of color and freshness.

Before You Start: Equipment

• Large pot – To boil the lasagna noodles.
• Colander – For draining the noodles.
• Mixing bowls – To combine the cheeses and seasonings.
• 9×13 inch casserole dish – Ideal size for layering and baking.
• Cheese grater – If you’re grating your own mozzarella and Parmesan.
• Spatula or spoon – For spreading the sauce and cheese evenly.
• Aluminum foil – To cover the casserole while baking and avoid over-browning.

Chicken Alfredo Lasagna Casserole — Do This Next

Step 1: Prepare the Noodles

Bring a large pot of salted water to a boil. Add the lasagna noodles and cook according to the package directions until al dente. Drain and set aside on a lightly oiled sheet to avoid sticking.

Step 2: Mix the Cheese Filling

In a medium bowl, combine the ricotta cheese, half of the shredded mozzarella (1 ½ cups), grated Parmesan, garlic powder, Italian seasoning, salt, and pepper. Stir thoroughly to blend all the flavors.

Step 3: Assemble the Layers

Preheat your oven to 375°F (190°C). Spread a thin layer of Alfredo sauce on the bottom of your casserole dish. Lay down 4 lasagna noodles side by side. Spread half of the ricotta mixture over the noodles, then sprinkle with 1 cup of shredded chicken. Drizzle with about 1 cup of Alfredo sauce and sprinkle with 1 cup mozzarella.

Repeat these layers: noodles, ricotta mixture, chicken, Alfredo sauce, mozzarella. Finish with a final layer of noodles, the remaining Alfredo sauce, and the last 1 cup mozzarella cheese on top.

Step 4: Bake

Cover the casserole dish tightly with aluminum foil. Bake for 25 minutes. Remove the foil and bake for another 15 minutes, or until the cheese is bubbly and golden brown.

Step 5: Garnish and Serve

Let the casserole cool for 10 minutes before serving. Garnish with freshly chopped parsley for a touch of color and freshness.

Dairy-Free/Gluten-Free Swaps

• Gluten-Free Lasagna Noodles: Substitute regular noodles with gluten-free lasagna sheets available in most grocery stores.
• Dairy-Free Alfredo Sauce: Use a plant-based Alfredo sauce made from cashews or cauliflower.
• Dairy-Free Cheese: Replace ricotta, mozzarella, and Parmesan with vegan cheese alternatives that melt well.
• Chicken Alternatives: For a vegetarian twist, swap shredded chicken with sautéed mushrooms or zucchini slices.

Author’s Commentary

This Chicken Alfredo Lasagna Casserole has quickly become one of my favorite ways to mix up traditional lasagna night. What I love most is how creamy and indulgent the Alfredo sauce makes the dish without overpowering the tender chicken and cheeses. The layering is straightforward, which makes it beginner-friendly, yet the flavors feel elevated enough to impress guests.

One tip I always share is to use freshly grated Parmesan for that authentic salty bite. Also, make sure not to overcook your noodles so they hold up well in the casserole. This recipe pairs beautifully with a simple green salad or some roasted vegetables.

If you’re a fan of cheesy baked pasta dishes, you might want to check out my Baked Four Cheese Lasagna Roll Ups or the comforting Baked Three Cheese Chicken Penne for more crowd-pleasing ideas.

Save for Later: Storage Tips

• Refrigerator: Store leftovers in an airtight container for up to 4 days.
• Freezer: This casserole freezes beautifully. Cover tightly with foil and freeze for up to 3 months. Thaw overnight in the fridge before reheating.
• Reheating: Warm individual portions in the microwave or reheat the whole casserole at 350°F (175°C) covered with foil until heated through.

Your Top Questions

Can I use pre-cooked chicken from the store for this casserole?

Absolutely! Using pre-cooked rotisserie chicken is a fantastic shortcut that saves time and adds flavor. Just shred it before layering into the casserole.

Do I need to boil the lasagna noodles, or can I use no-boil noodles?

You can use no-boil noodles if you prefer. Just ensure your Alfredo sauce is slightly thinner to help cook the noodles fully in the oven. With regular noodles, boil them until al dente before assembling.

Is it possible to add vegetables to this casserole?

Yes! Adding sautéed spinach, mushrooms, or zucchini can add extra flavor and nutrition. Just layer them in with the chicken or mix them into the ricotta cheese filling.

How can I make this recipe lighter without losing flavor?

You can substitute part of the ricotta with low-fat cottage cheese, use a lighter Alfredo sauce, or reduce the amount of mozzarella. Adding more vegetables also helps bulk up the dish with fewer calories.

More Recipes You’ll Love

• Baked Four Cheese Lasagna Roll Ups – A cheesy, elegant twist on classic lasagna.
• Baked Three Cheese Chicken Penne – A creamy, baked pasta perfect for weeknight dinners.
• Creamy Spinach and Artichoke Dip – Perfect for appetizers or game day snacking.
• Garlic Parmesan Roasted Carrots – A simple side that pairs well with any casserole.

That’s a Wrap

Chicken Alfredo Lasagna Casserole is the ultimate comfort food that brings together creamy Alfredo sauce, tender chicken, and layers of cheese and noodles for a truly satisfying meal. Whether you’re feeding a crowd or craving a cozy dinner, this recipe is sure to become a favorite in your kitchen. With easy prep, flexible ingredients, and rich flavor, it’s a dish you can rely on again and again. So grab your casserole dish, get those noodles boiling, and treat yourself to a slice of cheesy, creamy lasagna perfection tonight.

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